Gynecological manifestations, histopathological findings, and schistosoma-specific polymerase chain reaction results among women with Schistosoma haematobium infection: a cross-sectional study in Madagascar

The Journal of Infectious Diseases
Bodo Sahondra RandrianasoloEyrun Floerecke Kjetland

Abstract

The pathophysiology of female genital schistosomiasis (FGS) is only partially understood. This study aims to describe the histopathological findings, polymerase chain reaction (PCR) results, and gynecological manifestations of FGS in women with different intensities of Schistosoma haematobium infection. Women aged 15-35 years living in an S. haematobium-endemic area in Madagascar underwent pelvic and colposcopic examinations. Small biopsy specimens were obtained from lesions and examined histopathologically. Schistosoma PCR was done on urine, biopsy, cervicovaginal lavage, and genital mucosal surface specimens. Sandy patches and rubbery papules were found in 41 of 118 women (35%). Rubbery papules reflected an intense cellular immune reaction dominated by eosinophils, epithelial erosion, and viable ova. There was a significant decrease in the prevalence of rubbery papules with age, even after adjustment for urinary ova excretion. The sandy patches with grains showed moderate cellular immune reaction and ova (viable and/or calcified). They were most prevalent in cases with low-intensity urinary S. haematobium infection. Forty-two percent of women with Schistosoma-negative urine specimens had at least 1 genital specimen test posit...Continue Reading

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Citations

Jan 30, 2016·Parasites & Vectors·Clara Fabienne RasoamanamihajaPeter Mark Jourdan
Apr 12, 2016·International Journal for Parasitology·Vanessa ChristinetJutta Reinhard-Rupp
Feb 8, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel P OʼBrienVanessa Christinet
Aug 11, 2018·Nature Reviews. Disease Primers·Donald P McManusXiao-Nong Zhou
Feb 23, 2020·Seminars in Immunopathology·Donald P McManusHong You
Apr 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martine DelavyPierre Vassilakos
Dec 18, 2020·Frontiers in Immunology·Alisha ChettyWilliam Horsnell
Aug 3, 2021·Open Forum Infectious Diseases·Amy S SturtAmaya L Bustinduy

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Methods Mentioned

BETA
biopsy
PCR
lavage
biopsies

Software Mentioned

EpiInfo
Statistical Package for the Social Sciences

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