Gynecological sarcomas: what's new in 2018, a brief review of published literature

Current Opinion in Oncology
Justine Gantzer, Isabelle Ray-Coquard

Abstract

In this article, we focus on recent published data (2017) on the management of gynecologic sarcomas. The most significant data published in 2017 develop definition of a new molecular subtype of high grade endometrial stromal sarcoma (ESS) using molecular technics added to histological analysis. The identification of a new translocation on presumed uterine leiomyosarcoma (LMS) points to refinement of nosological classification, with fragmentation of even rare tumors into distinct molecular entities: gynecologic sarcomas are now distinguished into distinct entities from a heterogeneous group of tumors. Other articles have discussed the real incidence of unsuspected sarcomas after fibroid mini-invasive surgery and evaluate the risk of relapse and dissemination after morcellation. Among several criteria, preoperative imagery could become a useful tool. For systemic treatment, no clinical trials changing practices were published, only one positive nonrandomized phase II with carboplatin and pegylated liposomal doxorubicin (PLD) in the treatment of uterine sarcomas after the conventional first line, especially in LMSs and ESSs. Many articles were published on this confidential domain in oncology demonstrating interests on rare sarcom...Continue Reading

References

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Citations

Jun 21, 2020·Cell Biology and Toxicology·Karolina KowalskaAgnieszka Wanda Piastowska-Ciesielska
Mar 9, 2019·International Journal of Molecular Sciences·Piotr RubiszChristopher Kobierzycki
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
Jun 28, 2020·European Journal of Hospital Pharmacy. Science and Practice·Yao ZhuXiaoling Zheng
Apr 1, 2021·Medicine·Anastasios KyriazoglouMaria Gavriatopoulou

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Methods Mentioned

BETA
hysterectomy

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