Gypenosides alleviate myocardial ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function in rat heart

Cell Stress & Chaperones
Haijie YuYingxian Sun

Abstract

Gypenosides (GP) are the predominant components of Gynostemma pentaphyllum, a Chinese herb medicine that has been widely used for the treatment of chronic inflammation, hyperlipidemia, and cardiovascular disease. GP has been demonstrated to exert protective effects on the liver and brain against ischemia-reperfusion (I/R) injury, yet whether it is beneficial to the heart during myocardial I/R is unclear. In this study, we demonstrate that pre-treatment with GP dose-dependently limits infarct size, alleviates I/R-induced pathological changes in the myocardium, and preserves left ventricular function in a rat model of cardiac I/R injury. In addition, GP pre-treatment reduces oxidative stress and protects the intracellular antioxidant machinery in the myocardium. Further, we show that the cardioprotective effect of GP is associated with the preservation of mitochondrial function in the cardiomyocytes, as indicated by ATP level, enzymatic activities of complex I, II, and IV on the mitochondrial respiration chain, and the activity of citrate synthase in the citric acid cycle for energy generation. Moreover, GP maintains mitochondrial membrane integrity and inhibits the release of cytochrome c from the mitochondria to the cytosol. Th...Continue Reading

References

Jan 1, 1991·Free Radical Research Communications·J F TurrensJ M McCord
Jan 5, 2000·Heart·E J Topol
Sep 22, 2000·The American Journal of Chinese Medicine·J C ChenW C Wang
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·E J LesnefskyC L Hoppel
Feb 14, 2004·Cardiovascular Research·Andrew P HalestrapSabzali A Javadov
Feb 14, 2004·Cardiovascular Research·Stephen C Armstrong
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Aug 19, 2008·Lancet·Harvey D White, Derek P Chew
May 11, 2010·Acta Pharmacologica Sinica·Shuang ZhangShi-jie Yang
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Roberta A Gottlieb
Oct 3, 2013·European Heart Journal·Stuart J HeadA Pieter Kappetein
Oct 3, 2013·European Heart Journal·Stuart J HeadArie Pieter Kappetein
Apr 11, 2015·Journal of the American College of Cardiology·Borja IbáñezFrans Van de Werf

❮ Previous
Next ❯

Citations

Feb 11, 2020·Natural Product Research·Wei-Ye CuiXiang-Lan Piao
Dec 19, 2017·Experimental and Therapeutic Medicine·Gerburg KeilhoffLorenz Schild
Jul 19, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Bombi LeeHyejung Lee
Apr 23, 2020·Frontiers in Pharmacology·Abdullah ShaitoGianfranco Pintus
Nov 14, 2020·Journal of Ethnopharmacology·Ngoc-Hieu NguyenWon Keun Oh
Oct 14, 2020·Experimental Eye Research·Reem Hasaballah AlhasaniXinhua Shu
May 18, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wen FuHuixia Lv
Aug 18, 2020·Ecotoxicology and Environmental Safety·Yiming ZhangShu Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.