PMID: 6402447Jan 1, 1983Paper

H-2 effects on cell-cell interactions in the response to single non-H-2 alloantigens. VI. H-2Kb mutants differentially regulate the immune response to the H-4.2 alloantigen

Immunogenetics
P J Wettstein, R W Melvold

Abstract

Mice expressing mutant H-2Kb alleles were tested for their ability to generate cytotoxic effector T-cells specific for the non-H-2 histocompatibility alloantigen H-4.2. Cytotoxic effectors specific for H-4.2 are preferentially restricted by the Kb allele. Mutant Kb alleles were observed to differentially regulate the magnitude of the H-4.2-specific cytotoxic effector response. Mice expressing the Kbm5, Kbm6, Kbm7, and Kbm9 alleles generated cytotoxic T-cells to the same level as mice expressing the wild-type Kb allele. Kbm8 and Kbm11 responders generated intermediate levels of effectors, whereas Kbm1, Kbm3, and Kbm10 responders did not generate detectable levels of cytotoxic effectors. Kbm4 responders produced high levels of H-4.2-specific cytotoxic effectors that were variably reactive with wild-type Kb antigens with no H-4.2. The ability to generate H-4.2-specific effectors generally correlated with (1) the ability of mutant Kb molecules to present H-4.2 to wild-type Kb-restricted effectors, and (2) the position of the respective amino acid interchanges on the Kb molecule. Mutations that altered the amino acid sequence in the vicinity of the disulfide bond in the C1 domain had the greatest deleterious effects on Kb-controlled...Continue Reading

References

Jan 1, 1978·Immunological Reviews·M Zaleski, J Klein
Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Jan 1, 1978·Scandinavian Journal of Immunology·R H Schwartz
Oct 1, 1978·European Journal of Immunology·E SimpsonD Bailey
Jun 1, 1977·The Journal of Experimental Medicine·M Zaleski, J Klein
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P J WettsteinJ A Frelinger
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C TerhorstJ L Strominger
Oct 1, 1973·Journal of Immunological Methods·A B Peck, F H Bach
Feb 1, 1972·Cellular Immunology·R E ClickB J Alter
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·E T Angelakos, M P King
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J B RothbardB A Cunningham
Jan 1, 1982·The Journal of Experimental Medicine·T R Hünig, M J Bevan
Jan 1, 1980·Annual Review of Genetics·R NairnS G Nathenson
May 7, 1981·Nature·J E ColiganS G Nathenson
Apr 1, 1960·Transplantation Bulletin·D W BAILEY, B USAMA

❮ Previous
Next ❯

Citations

Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y BushkinE A Boyse
Jul 1, 1986·Immunology Today·B Loveland, E Simpson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.