H-2 gene products influence susceptibility of target thyroid gland to damage in experimental autoimmune thyroiditis

European Journal of Immunology
A Ben-NunI R Cohen

Abstract

The restriction of the pathogenesis of experimental autoimmune thyroiditis (EAT) by H-2 gene products was investigated. EAT was induced by injecting thyroglobulin extract plus adjuvant into F1 hybrid mice that had been implanted under the kidney capsules with thyroid glands originating from either the EAT-susceptible or -resistant parental strain mice. We found relative H-2 restriction of thyroid damage to those glands originating from the H-2 susceptible parental strain. H-2 restriction of damage at the level of the target thyroid gland implicates cytotoxic effector T lymphocytes as a pathogenic agent of EAT.

References

Jan 1, 1978·Advances in Immunology·J Klein
Nov 1, 1975·Clinical Immunology and Immunopathology·V Tomazic, N R Rose
Dec 25, 1971·Lancet·A C Allison
Mar 1, 1974·The Journal of Experimental Medicine·J A Clagett, W O Weigle
Jan 1, 1967·British Medical Bulletin·I M Roitt, D Doniach
Sep 1, 1970·Cellular Immunology·P Perlmann, H Perlmann

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Citations

Feb 1, 1983·The Journal of Experimental Medicine·P CreemersY M Kong
Dec 1, 1990·Journal of Immunogenetics·C J KrcoY M Kong
Aug 1, 1982·Journal of Immunogenetics·K W BeiselN R Rose
Jun 1, 1983·Immunology Today·A CookeI M Roitt
Nov 1, 1987·Cellular Immunology·W V WilliamsH Braley-Mullen
Aug 1, 1981·Clinical Immunology and Immunopathology·I OkayasuN R Rose
Jan 1, 1992·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B W RitchieP D Lukert
Sep 1, 1988·Clinical Immunology and Immunopathology·S C KnightC Bateman

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