PMID: 3156401Feb 1, 1985

H-2-linked Ir genes have a striking influence on the immunogenicity of idiotopes of myeloma protein 315 for T helper cells

Scandinavian Journal of Immunology
T JørgensenK Hannestad

Abstract

H-2-linked immune response (Ir) genes control T helper cells (Th) that recognize idiotopes of the V domains of myeloma protein 315 as carriers; Th recognition was detected by augmentation of antibody responses of hapten (4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP]-primed B cells boosted with NIP conjugated to Fab315. The present study indicates that the responder k allele of the Ir VH315 gene maps to the I-A subregion of H-2. A responder s allele of the Ir V lambda 2(315) gene on an A-strain background was identified, which also most likely maps to I-A. Although the d allele of the Ir V lambda 2(315) gene is a responder allele on DBA/2 background, the D2.GD strain (with I-region haplotype AdBbJbEbCb) was non-responder to V lambda 2(315), suggesting either that the responder d allele maps to I-E or that the b allele of a second Ir V lambda 2(315) gene located to the right of I-A exerts a strong suppressive influence. The H-2b haplotype conferred non-responsiveness to VH315, V lambda 2(315), and Fv315.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A BerzofskyD J Killion
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S TonegawaW Gilbert
Jun 1, 1975·The Journal of Experimental Medicine·N Sakato, H N Eisen
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·S Sirisinha, H N Eisen
Sep 1, 1982·Immunology Today·W E Paul, C Bona

Citations

Jan 1, 1993·International Reviews of Immunology·B Bogen, S Weiss
Jun 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Hannestad, Helge Scott
Nov 1, 1988·European Journal of Immunology·G Kristoffersen, K Hannestad
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·K Hannestad, G Kristoffersen

Related Concepts

Immune-Associated Antigens
Genome Mapping
Ir Genes
H-2 Antigens
Haploid Cell
Helper-Inducer T-Lymphocyte
Immunoglobulin Idiotypes
Framework Region, Immunoglobulin
Immunoglobulin Heavy Chain Subgroup VH-III
Lambda-x Immunoglobulin

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