PMID: 6168725Sep 1, 1981Paper

H-2-restricted helper factor secreted by clone hybridoma cells

The Journal of Experimental Medicine
P LonaiG J Hämmerling

Abstract

Biological and serological characteristics of a helper factor secreted by cloned hybridoma cells was described. The factor is carrier specific and contains determinants shared with immunoglobulin VH bu does not react with V kappa- or V lambda-specific antibodies. Presence of four H-2I-controlled antigenic specificities, Ia.ml, Ia.m2, Ia.17, and Ia.m7, was detected. Hence, it is possible that both A beta and E alpha loci may be involved in its control. Helper effect could be obtained only toward B cell sources that shared the H-2K and I-A antigens with the hybridoma cells. Similarly, the factor was absorbed only by spleen cells syngeneic in I-A. Previous studies have demonstrated that this clone binds antigen in an H-2-restricted manner. It follows that H-2-restricted helper cells produce H-2-restricted helper factors. Hence, they support the view that specific T cell factors may represent secreted T cell receptors.

References

Jan 1, 1979·Annals of the New York Academy of Sciences·M J TaussigA Holliman
Oct 1, 1978·The Journal of Experimental Medicine·P P JonesH O McDevitt
Aug 3, 1978·Nature·S KontiainenM Feldmann
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Dec 1, 1980·Immunology·M J Taussig
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P LonaiG Hämmerling

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Citations

Jan 1, 1982·Immunogenetics·M SuzanB Rubin
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J LeW Prensky
Jun 1, 1985·Scandinavian Journal of Immunology·J L McKimm-Breschkin, J F Miller
Sep 30, 1982·Journal of Immunological Methods·C L Reading

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