PMID: 6966404Apr 1, 1980Paper

H-2 restriction: independent recognition of H-2 and foreign antigen by a single receptor

Proceedings of the National Academy of Sciences of the United States of America
R F SilicianoH S Shin

Abstract

We describe two situations in which the recognition of hapten can compensate for the lack of recognition of appropriate H-2 gene products in hapten-specific, H-2 restricted, T lymphocyte-mediated cytolysis. First, we show that although recognition of appropriate H-2 gene products is essential for the lysis of target cells bearing a low hapten density, significant hapten-specific lysis of H-2 inappropriate target cells is observed at high levels of target cell derivatization. Secondly, we show that hapten-conjugated anti-H-2 antibody inhibits cytolysis poorly even though its binding to target cell H-2 antigens is equivalent to that of underivatized antibody. These results suggest that hapten and H-2 are recognized independently and are therefore inconsistent with the altered-self model. Although our data do not exclude the dual-recognition model, we prefer to interpret them within the framework of a single-receptor model in which hapten and H-2 are recognized independently by receptors of identical idiotype on the T cell. We postulate that the affinity of these receptors for the relevant H-2 gene product is low enough so that the T cell is not activated by encounters with normal-self cells expressing that H-2 gene product. Howev...Continue Reading

References

Mar 1, 1976·The Journal of Experimental Medicine·R C Kuppers, C S Henney
Jan 1, 1971·European Journal of Immunology·N K Jerne

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