H. pylori and GERD: is less more?

The American Journal of Gastroenterology
John E PandolfinoPeter J Kahrilas

Abstract

Does chronic Helicobacter pylori gastritis prevent gastroesophageal reflux disease (GERD) and its sequelae? Yes, no, life should be so simple. A quick Medline search on the paired terms identified 527 citations since 1988 and that tells you something right there. Evidently, this is a complex relationship and attempting to reduce it to a yes/no answer is just not going to work. Perusing the literature, it becomes apparent that some combination of three component questions are in fact being asked: (i) Is it biologically plausible that H. pylori gastritis will reduce the occurrence of GERD? (ii) Is there an inverse epidemiological relationship between H. pylori infection and GERD? and (iii) Will the eradication of H. pylori unleash an epidemic of GERD? Each of these questions entails a unique set of consideration. We will consider each in turn.

References

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Citations

Jan 15, 2014·The American Journal of Gastroenterology·Lori A FischbachHashem B El Serag
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Sep 15, 2004·Journal of Clinical Gastroenterology·Grigoris I Leontiadis, Colin W Howden
Jan 19, 2005·The American Journal of Gastroenterology·Jannis KountourasDimitrios Chatzopoulos
Jun 20, 2007·Journal of Clinical Gastroenterology·Diklar MakolaSheila E Crowe
Feb 20, 2014·Internal and Emergency Medicine·Marilia CarabottiCarola Severi
Jun 20, 2018·The American Journal of Gastroenterology·Colin W Howden
Dec 14, 2005·Current Problems in Surgery·Bruce E StabileDavid L Weeks

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