Dec 19, 1975

H+ transport and membrane-bound HCO - 3 ATPase in salivary duct epithelium

Pflügers Archiv : European journal of physiology
U Wais, H Knauf

Abstract

An ATPase stimulated by HCO - ions and other oxybases and inhibited by SCN- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting HCO - 3 ions. No such ATPase was found in the rabbit duct, which normally does not secrete HCO - 3. The HCO - 3 ATPase was localized in the plasma membrane fraction of the homogenate, as evidenced by the marker 5'-nucleotidase. The activities of the HCO - 3 ATPase increased in metabolic alkalosis and decreased in metabolic acidosis in parallel to secretion of HCO - 3 and K+ ions by the duct epithelium. These findings provide further evidence that the membrane-bound HCO - 3 ATPase is involved in active H+/HCO - 3 transport.

Mentioned in this Paper

Microsomes
Potassium
Carbonic Acid Ions
Hydrogen
Mesothelium
Chinchilla Rabbits
Mitochondria
DNA-dependent ATPase
Submandibular Gland
Acidosis

About this Paper

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