H(+)-transporting ATP synthases: insights into how their electrochemically driven motor might serve as a drug target

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Masatomo Maeda

Abstract

ATP synthases, widely distributed in bacteria, eukaryotic mitochondria and chloroplasts, are highly conserved multi-subunit complexes. Although the conserved acidic residue in the transmembrane helix of the c subunit functions in proton transport, the surrounding residues differ among species. Such divergence could lead to different regulatory modes since pH-dependent proton transport has been demonstrated in Escherichia coli with a c subunit carrying an additional acidic residue in the helix. There is further divergence in the number of c subunits that form the ring structure in F(0). Recently, it was also suggested that certain chemicals recognize the a and c subunits of pathogenic bacterial F(0). Since there may be structural divergence even in well-conserved ATP synthases, the c subunit-ring as well as the a subunit in F(0) could be targets for drugs for specific bacterial species.

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Citations

May 14, 2011·International Journal of Antimicrobial Agents·Leonard AmaralJean-Marie Pagès

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