H19 and IGF2 gene expression in human normal, hyperplastic, and malignant endometrium

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
V TanosA Hochberg

Abstract

We examined H19 and insulin-like growth factor 2 (IGF2) gene expression in normal endometrium (12 cases), hyperplasia (27 cases), and cancer (27 cases) by non-radioactive in situ hybridization. H19 was not expressed in the epithelium of normal endometrium, but its frequency of expression was 15% in hyperplastic and 60% in neoplastic epithelium. In stroma cells, H19 frequency of expression was 75% in normal endometrium, 55% in hyperplasia, and 37% in carcinoma. According to the grade of endometrial cancer cell differentiation, H19 showed increased frequency and level of expression in the epithelium from well to moderately and poorly differentiated tissues. Our results indicate that H19 expression in epithelial cells of endometrial hyperplasia and cancer merits further investigation and could be useful as a complementary histopathologic and prognostic marker among other modalities in endometrial cancer. IGF2 expression did not appear useful for diagnostic or prognostic purposes.

References

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Citations

Sep 29, 2005·Journal of Clinical Pathology·Y FelligA Hochberg
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Feb 26, 2013·PloS One·Björn Reinius, Chandrasekhar Kanduri
Feb 4, 2014·Molecular Human Reproduction·Juan Manuel Moreno-MoyaCarlos Simón
Nov 12, 2015·International Journal of Molecular Sciences·Maria A SmolleJohannes Haybaeck
Jan 1, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Umit KorucuogluSevda Menevse
Nov 5, 2016·Cancer Genetics·Konii TakenakaMichael Janitz
Jun 24, 2017·Molecular Cancer·Elahe Seyed HosseiniZatollah Asemi
Aug 1, 2015·Cancers·Karrie Mei-Yee KiangGilberto Ka-Kit Leung
Apr 29, 2018·Molecular Cancer·Joëlle El HajjEvelyne Ségal-Bendirdjian
Nov 24, 2018·Future Oncology·Nadiah AbuRahman Jamal
Apr 2, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Montserrat SolanasEduard Escrich
Aug 22, 2018·Oncology Letters·Bi-Lan Li, Xiao-Ping Wan
Feb 1, 2017·Molecular Cancer·Xuefei WangJi-Long Chen
Apr 4, 2021·International Journal of Molecular Sciences·Roberto PiergentiliFederica Perelli
May 27, 2021·Clinical Epigenetics·Alejandra Monserrat Retis-ResendizEdgar Ricardo Vázquez-Martínez
Aug 28, 2021·Healthcare·Anna Franca CavaliereFabrizio Signore

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