H19 serves as a diagnostic biomarker and up-regulation of H19 expression contributes to poor prognosis in patients with gastric cancer

Neoplasma
J S ChenT P Xu

Abstract

Emerging evidences indicate that dysregulated long noncoding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression and might be used as diagnosis and prognosis biomarker, or potential therapeutic targets. LncRNA H19 has been reported to be upregulated in diverse human cancers; however, its clinical significance in gastric cancer (GC) remains elusive. Expression levels of H19 in 128 pairs of GC and adjacent normal tissues, GC cell lines and GC juices compared to their corresponding controls were detected by real-time quantitative polymerase chain reaction (qPCR) assay. A receiver operating characteristic (ROC) curve and Kaplan-Meier analysis were constructed to evaluate the diagnostic and prognostic values. Univariate and multivariate analysis were performed using the Cox proportional hazard analysis. H19 expression was remarkably increased in GC tissues and cell lines compared with that in the normal control, and its up-regulation was significantly correlated to invasion depth (P < 0.001), advanced TNM stage (P = 0.002) and regional lymph nodes metastasis (P < 0.001) in GC. H19 levels were robust in differentiating GC tissues from controls [area under the curve (AUC) = 0.697; 95% confidence interval (CI) = 0.636-...Continue Reading

Citations

Sep 9, 2016·International Journal of Molecular Sciences·Stefanie CerkMartin Pichler
Nov 4, 2017·International Journal of Molecular Sciences·Jordan ColletteEric Adriaenssens
Feb 5, 2019·Briefings in Bioinformatics·Xin QiBairong Shen
Aug 30, 2018·Non-coding RNA·Mabel Yin-Chun YauChi-Ming Wong
Apr 21, 2020·Pharmacogenomics and Personalized Medicine·Jang Hee HongJae Kyu Sung
Jul 24, 2020·Journal of Experimental & Clinical Cancer Research : CR·Yuhui ZhangChanghua Zhang
Apr 26, 2018·Breast Cancer Research and Treatment·Hidetaka ShimaItaru Endo
Aug 23, 2016·World Journal of Gastroenterology : WJG·Meng Zhang, Xiang Du
Dec 31, 2020·Cancer Management and Research·Jingrong YuJianping Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zheng-Hua FeiCong-Ying Xie
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Q ZhengP Chen
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Su-Xiu ChenZheng-Hua Fei
International Journal of Clinical and Experimental Pathology
Chen-Yu WangJun-Hong Hu
© 2022 Meta ULC. All rights reserved