H1/pAIM2 nanoparticles exert anti-tumour effects that is associated with the inflammasome activation in renal carcinoma

Journal of Cellular and Molecular Medicine
Dafei ChaiJunnian Zheng

Abstract

Renal cell carcinoma (RCC) is a high metastasis tumour with less effective treatment available currently. Absent in melanoma 2 (AIM2) as a tumour suppressor might be used as a potential therapeutic target for RCC treatment. Here, we found that AIM2 expression was significantly decreased in RCC patient specimens and renal carcinoma cell lines (786-O and OSRC-2). To establish a safe and effective AIM2 gene delivery system, we formed the nanoparticles consisting of a folate grafted PEI600-CyD (H1) nanoparticle-mediated AIM2 gene (H1/pAIM2) as an effective delivery agent. Delivery of H1/pAIM2 in renal carcinoma cells could remarkably increase the expression of AIM2, and subsequently decrease cell proliferation, migration, and invasion as well as enhance cell apoptosis. In order to evaluate the therapeutic efficacy of AIM2 in vivo, H1/pAIM2 nanoparticles were injected intratumorally into 786-O-xenograft mice. Administration of H1/pAIM2 nanoparticles could inhibit the tumour growth as evidenced by reduced tumour volume and weight. Furthermore, Blockade of inflammasome activation triggered by H1/pAIM2 nanoparticles using inflammasome inhibitor YVAD-CMK abrogated the anti-tumoral activities of H1/AIM2. These results indicated the thera...Continue Reading

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Citations

Dec 25, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiaomin MaLihui Han
Jun 28, 2019·Journal of Hematology & Oncology·Shengchao XuChunfang Zhang
Oct 20, 2020·Frontiers in Oncology·Giuseppe SchepisiUgo De Giorgi
May 21, 2021·Immunity, Inflammation and Disease·Huan ZhuHaijing Wu

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Methods Mentioned

BETA
transfection
scraping
xenograft
flow cytometry
flowcytometry
ELISA
xenografts

Software Mentioned

FACSDiva
ACT
SPSS

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