PMID: 6160781Jun 1, 1980Paper

H2 antihistamines (cimetidine) and allergic-inflammatory reactions

Allergy
S NornP S Skov

Abstract

Experiments in the skin and synovialis have thrown new light on the allergic-inflammatory reactions. The inflammatory effect of histamine is thus due to stimulation of two different types of receptors in the vessels, i.e. histaminergic H1 and H2 receptors. Both types of receptors are of importance for the immediate cutaneous response to allergens and histamine. Treatment with a combination of H1 antagonists (classical antihistamines) and the H2 antagonist cimetidine will thus cause a much stronger inhibition of the urticarial reactions than treatment with the H1 and H2 antagonist alone. It is therefore probable that a combination therapy could have an advantage over the traditional treatment with classical antihistamines in urticaria and other histamine-mediated skin diseases. Histamine might also be of importance for the swelling of the joints in inflammatory diseases such as rheumatoid arthritis, and clinical trials with H1 and H2 antagonists are in progress.

References

Sep 1, 1978·Clinical Allergy·P PhanuphakP F Kohler
Jun 1, 1979·The Journal of Allergy and Clinical Immunology·M Plaut
Jan 1, 1979·Annual Review of Pharmacology and Toxicology·B I Hirschowitz
Dec 1, 1978·The British Journal of Dermatology·C A Commens, M W Greaves
Jul 1, 1977·British Journal of Pharmacology·M M Dale
Jun 1, 1979·Annals of Internal Medicine·F H Al-KawasR A Sacher
Jul 1, 1977·European Journal of Pharmacology·R D Krell, L W Chakrin
Feb 1, 1975·European Journal of Clinical Investigation·D M Grennan
May 24, 1974·Nature·D M GrennanW C Dick
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Nov 1, 1969·Acta Allergologica·G GranerusT White
Sep 1, 1980·Allergy·O LöwhagenH Wetterqvist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.