H2-D(d)-mediated upregulation of interleukin-4 production by natural killer T-cell and dendritic cell interaction

Immunology
Kazuomi MizuuchiK Onoé

Abstract

Natural killer T (NKT) cells are capable of subserving apparently opposite functions, the interferon-gamma (IFN-gamma)-mediated enhancement of host defence and interleukin-4 (IL-4) -mediated immune regulation. Although dendritic cells (DCs) potently activate NKT cells, DC regulation of the IL-4-IFN-gamma balance via NKT-cell activation is not well characterized. In the present study, we examined the effect of DC treatment with CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 ligand, on the induction of NKT-cell cytokine production. CpG-ODN-conditioned and alpha-galactosylceramide (alpha-GalCer)-loaded myeloid DCs (CpG-DCs) from BALB/c mice showed enhanced ability to induce NKT-cell production of IL-4, but not IFN-gamma, compared to alpha-GalCer-loaded control DCs (not treated with CpG-ODN). The CpG-DCs expressed significantly higher levels of H2-D(d) than control DCs, and blocking of the H2-D(d) and Ly49 receptor interaction during antigen presentation completely abolished the enhanced ability of the CpG-DCs to induce NKT-cell production of IL-4. These findings demonstrate that DC recognition of the CpG motif leads to induction of enhanced IL-4 production by NKT cells via interaction of the augmented H2-D(d) with Ly49 rec...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H AraseK Onoé
Jan 1, 1993·European Journal of Immunology·H AraseK Onoé
Jan 20, 1997·The Journal of Experimental Medicine·C WinzlerP Ricciardi-Castagnoli
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z IllésT Yamamura
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y HayakawaK Okumura
May 24, 2001·Immunity·H Wagner
Aug 30, 2001·Nature Immunology·F GranucciP Ricciardi-Castagnoli
Jun 18, 2002·Trends in Molecular Medicine·Michael T WilsonLuc Van Kaer
Aug 30, 2002·Blood·Yoshiki Yanagawa, Kazunori Onoé
Apr 12, 2003·The Journal of Experimental Medicine·Roger B VoyleH Robson MacDonald
Jan 17, 2004·Journal of Leukocyte Biology·Alessandra Mazzoni, David M Segal
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie DillonBali Pulendran
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·José R Ramírez-PinedaHeidrun Moll
Jan 22, 2005·Immunology and Cell Biology·Nazzareno Dimasi, Roberto Biassoni
Jul 20, 2005·International Immunology·Norifumi IijimaKazunori Onoé
Mar 18, 2006·The Journal of Clinical Investigation·Stephanie DillonBali Pulendran
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Ray Chun-Fai ChanAndre E Nel

❮ Previous
Next ❯

Citations

Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alexander Y W Suen, Troy A Baldwin
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yan XingKristin A Hogquist
Apr 21, 2010·The Journal of Experimental Medicine·Wanli LiuSusan K Pierce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.