PMID: 8613139Jan 1, 1996Paper

H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove

Immunogenetics
W WalterM J Maeurer

Abstract

The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibility I-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequenced H2-Ma, H2-Mb1, and H2-Mb2 genes from CIA-susceptible and -resistant mouse strains and identified four different Ma and Mb2 alleles and three different Mb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share common Ma, Mb1, and Mb2 alleles. In contrast, H2-M alleles designated Ma-III, Ma-IV, Mb1-III, and Mb2-IV could be exclusively identified in the CIA-susceptible H2r and H2q haplotypes, suggesting that allelic H2-M molecules may modulate the composition of different CII peptides loaded into MHC class II molecules, presumably presenting "arthritogenic" epitopes to T lymphocytes.

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Citations

Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Tim FiedlerMarkus J Maeurer
Sep 1, 1997·Clinical Immunology and Immunopathology·G A HanleyE S Sobel

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