PMID: 9550293Apr 29, 1998Paper

H2 receptor-mediated facilitation and H3 receptor-mediated inhibition of noradrenaline release in the guinea-pig brain

Naunyn-Schmiedeberg's Archives of Pharmacology
J TimmE Schlicker

Abstract

The effect of histamine and related drugs on the tritium overflow evoked electrically (0.3 Hz) or by introduction of Ca2+ ions into Ca2+-free K+-rich (25 mmol/l) medium containing tetrodotoxin was studied in superfused guinea-pig brain cortex, cerebellum, hippocampus or hypothalamus slices and in mouse brain cortex slices preincubated with 3H-noradrenaline. The electrically evoked tritium overflow in guinea-pig cortex slices was inhibited by histamine; the H3 receptor antagonist clobenpropit reversed the effect of histamine to a slight facilitation. The facilitatory effect of histamine (obtained in the presence of clobenpropit) was not affected by the H1 receptor antagonist mepyramine but abolished by the H2 receptor antagonist ranitidine. In the absence of clobenpropit, ranitidine augmented the inhibitory effect of histamine. In slices superfused in the presence of ranitidine, the evoked overflow was inhibited by histamine and, more potently, by the H3 receptor agonist R-alpha-methylhistamine in a concentration-dependent manner (maximum inhibitory effect obtained for both agonists 30-35%). The concentration-response curve of histamine was shifted to the right by the H3 receptor antagonist thioperamide. R-alpha-methylhistamine ...Continue Reading

Citations

Oct 1, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·T SchultheissE Schlicker
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Oct 9, 1999·Progress in Neurobiology·C Gottesmann
Aug 9, 2007·Neuroscience Letters·Marcos A MayerAna M Puyó
Sep 3, 2008·Journal of Neurochemistry·Sarah ThrelfellSusan A Greenfield
Oct 11, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Monika FeliszekEberhard Schlicker
Oct 19, 2016·Molecular Pharmacology·Gustavo Nieto-AlamillaJosé-Antonio Arias-Montaño
Dec 18, 2001·The Journal of Comparative Neurology·J Kaslin, P Panula
Feb 23, 1999·Fundamental & Clinical Pharmacology·E SchlickerJ Zentner
Jan 1, 2014·Cerebellum & Ataxias·Bin LiJian-Jun Wang

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