PMID: 8584210Aug 11, 1995Paper

H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin

Neuroscience Letters
E SewerynekR J Reiter

Abstract

Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H2O2 (0.1-5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1-5 mM) protected against H2O2-induced lipid peroxidation of brain homogenates in a concentration-dependent manner.

References

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Citations

Sep 9, 2004·Journal of Physiology and Biochemistry·J BarrenetxeJ A Martínez
Apr 26, 2005·Journal of Neuroscience Methods·Yngo J GarciaNancy Peñaloza
Nov 24, 1998·Biochemical Pharmacology·C E BeyerD Saphier
Aug 30, 2001·European Journal of Pharmacology·S Cuzzocrea, R J Reiter
Jan 1, 1997·Life Sciences·E GiladC Szabó
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Pattipati S NaiduShrinivas K Kulkarni
Mar 3, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·H KabutoR P. Liburdy
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wei WangAnil K Jaiswal
Apr 28, 2006·Journal of Gastroenterology and Hepatology·Hiroaki TaniokaNorio Koide
Dec 1, 2001·Pediatric Research·P A Dennery
Feb 13, 2001·Journal of Molecular and Cellular Cardiology·R SalieA Lochner
Dec 1, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Eugenia Murawska-CiałowiczPiotr Dzięgiel
Aug 5, 2008·European Journal of Pharmacology·Caroline CapitelliMaria Aparecida Barbato Frazão Vital
Mar 11, 2004·Journal of Pineal Research·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Mohamed Amine ZaoualiJoan Roselló-Catafau
Aug 15, 2012·Toxicology Mechanisms and Methods·Divya SurendranP V Mohanan
Aug 8, 2018·Canadian Journal of Physiology and Pharmacology·Natalia KurhalukPawel J Winklewski

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