PMID: 8612796Mar 25, 1996Paper

H2O2 renders cells accessible to lysis by exogenous phospholipase A2: a novel mechanism for cell damage in inflammatory processes

FEBS Letters
P DanS Yedgar

Abstract

Phospholipase A2 (PLA2) and H2O2, secreted from activated inflammatory cells, play a central role in the tissue damage occurring in inflammatory processes. However, while exogenous PLA2 alone does not cause cell lysis, it readily does so when acting with H2O2. We have found that H2O2 degrades cell surface proteoglycans, thus rendering the membrane PL accessible to hydrolysis by exogenous PLA2. This novel mechanism introduces a role for cell surface proteoglycans in protection of cells from damage by pro-inflammatory agents, and may assign a central role for the combined action of H2O2 and PLA2 in inflammatory and bacteriocidal processes.

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Citations

May 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KrimskyM Ligumsky
Jul 9, 2003·Critical Care Medicine·Grietje Ch BeckSaul Yedgar
Mar 9, 2017·Physiological Reports·Shannon E KispertJane McHowat
Jul 31, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I Ginsburg
Jan 27, 2004·The Journal of Parasitology·Ariela Freudenstein-DanZvi Fishelson
Feb 5, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I Ginsburg
Nov 18, 2000·Biochimica Et Biophysica Acta·S YedgarE Schnitzer
Jul 11, 1997·Atherosclerosis·E Hurt-Camejo, G Camejo
May 14, 2003·Cellular Signalling·Sajal Chakraborti

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