H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure.

American Journal of Physiology. Heart and Circulatory Physiology
Paras K MishraSuresh C Tyagi

Abstract

Reactive oxygen and nitrogen species (ROS and RNS, respectively) generate nitrotyrosine and activate latent resident myocardial matrix metalloproteinases (MMPs). Although in chronic heart failure (CHF) there is robust increase in ROS, RNS, and MMP activation, recent data suggest that hydrogen sulfide (H(2)S, a strong antioxidant gas) is cardioprotective. However, the role of H(2)S in mitigating oxidative and proteolytic stresses in cardiac remodeling/apoptosis in CHF was unclear. To test the hypothesis that H(2)S ameliorated cardiac apoptosis and fibrosis by decreasing oxidative and proteolytic stresses, arteriovenous fistula (AVF) was created in wild-type (C57BL/6J) mice. The hearts were analyzed at 0, 2, and 6 wk after AVF. To reverse the remodeling, AVF mice were treated with NaHS (an H(2)S donor, 30 micromol/l in drinking water) at 8 and 10 wk. The levels of MMPs were measured by gelatin-gel zymography. The levels of nitrotyrosine, tissue inhibitors of metalloproteinase (TIMPs), beta(1)-integrin, and a disintegrin and metalloproteinase-12 (ADAM-12) were analyzed by Western blots. The levels of pericapillary and interstitial fibrosis were identified by Masson trichrome stains. The levels of apoptosis were measured by identif...Continue Reading

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Citations

Feb 7, 2012·Antioxidants & Redox Signaling·Yi-Hong LiuJin-Song Bian
Jan 15, 2011·Journal of Applied Physiology·Srikanth GivvimaniSuresh C Tyagi
Apr 17, 2010·American Journal of Nephrology·Utpal SenSuresh C Tyagi
Sep 11, 2010·Cardiovascular Diabetology·Paras K MishraSuresh C Tyagi
May 10, 2013·Vascular Health and Risk Management·Thomas P VacekSuresh C Tyagi
Feb 2, 2013·Canadian Journal of Physiology and Pharmacology·Youngjun JuGuangdong Yang
Jun 6, 2015·International Journal of Molecular Sciences·Hui GongYunzeng Zou
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Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Guoliang MengYong Ji
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Nov 6, 2012·Biochemical and Biophysical Research Communications·Ming FuRui Wang
Oct 19, 2011·Toxicology and Applied Pharmacology·Yanxi PeiGuangdong Yang
Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Shufang ZhangGensheng Zhang
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Aug 16, 2013·Journal of Cellular and Molecular Medicine·Jingwei ShengPhilip Wong
Jun 17, 2020·Journal of Cellular Physiology·Yuqi ChenXiang Zhou
May 11, 2013·Molecular and Cellular Biochemistry·Fanghao LuWeihua Zhang
Feb 18, 2020·Oxidative Medicine and Cellular Longevity·Se Chan KangSung Ryul Lee
Nov 26, 2011·Expert Review of Clinical Pharmacology·Guangdong Yang
Jul 4, 2019·Canadian Journal of Physiology and Pharmacology·Anwesha LahaSuresh C Tyagi

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