H3 receptor renal expression in normal and diabetic rats

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Alessandro PiniArianna Carolina Rosa

Abstract

To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R. Kidney specimens from 24 8-week-old male Wistar rats (12 non-diabetic and 12 diabetic animals) were processed for both immunohistochemical and immunofluorescence analyses. H3R is expressed in the apical membrane by collecting duct cells in the kidney of rats and it is significantly increased in diabetic animals. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis.

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Citations

Jun 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessandro PiniArianna Carolina Rosa
Apr 21, 2018·Clinical and Experimental Pharmacology & Physiology·Eduardo Rivera-MancillaCarlos M Villalón
Feb 12, 2019·British Journal of Pharmacology·Cristina GrangeArianna Carolina Rosa
Jan 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kazuyuki NoguchiAkiyoshi Fukamizu
May 30, 2019·International Journal of Molecular Sciences·Roberta VertaArianna Carolina Rosa
Jan 5, 2019·Clinical Science·Alessandro PiniArianna Carolina Rosa

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