PMID: 22572731May 11, 2012Paper

H3S10 phosphorylation marks constitutive heterochromatin during interphase in early mouse embryos until the 4-cell stage

The Journal of Reproduction and Development
Karlla Ribeiro-MasonNathalie Beaujean

Abstract

Phosphorylation of histone H3 at Ser10 (H3S10P) has been linked to a variety of cellular processes, such as chromosome condensation and gene activation/silencing. Remarkably, in mammalian somatic cells, H3S10P initiates in the pericentromeric heterochromatin during the late G2 phase, and phosphorylation spreads throughout the chromosomes arms in prophase, being maintained until the onset of anaphase when it gets dephosphorylated. Considerable studies have been carried out about H3S10P in different organisms; however, there is little information about this histone modification in mammalian embryos. We hypothesized that this epigenetic modification could also be a marker of pericentromeric heterochromatin in preimplantation embryos. We therefore followed the H3S10P distribution pattern in the G1/S and G2 phases through the entire preimplantation development in in vivo mouse embryos. We paid special attention to its localization relative to another pericentromeric heterochromatin marker, HP1β and performed immunoFISH using specific pericentromeric heterochromatin probes. Our results indicate that H3S10P presents a remarkable distribution pattern in preimplantation mouse embryos until the 4-cell stage and is a better marker of peri...Continue Reading

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Citations

May 14, 2014·Human Molecular Genetics·Shawn L ChavezRenee A Reijo Pera
May 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Theo F J KrausHans A Kretzschmar
Mar 26, 2021·Biology of Reproduction·Shuang LiKun Zhang

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