H5N1 influenza virus evolution: a comparison of different epidemics in birds and humans (1997-2004)

The Journal of General Virology
Laura CampitelliGiovanni Rezza

Abstract

The selection pressure acting along the entire genome sequence of H5N1 avian influenza viruses isolated from several bird species and humans infected in the 1997 and 2004 outbreaks, and on the HA1 genes from H5N1 viruses isolated during the entire study period, in eastern Asia was evaluated. According to maximum-likelihood analysis, viral genes appeared to be, in both epidemics, under strong purifying selection, with only the PB2, HA and NS1 genes under positive selection. Specific codons under positive selection were detected by using codon-based substitution models. Positive-selection analysis performed on single-codon sites might be helpful in clarifying the driving force of avian and human influenza virus evolution and in selecting specific targets for vaccines and antiviral drugs.

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Citations

Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·Chutamas ThepmaleeDonruedee Sanguansermsri
Jul 2, 2010·Animal Health Research Reviews·Heather L Forrest, Robert G Webster
Jul 24, 2012·Molecular Biology and Evolution·Niv SabathDavid Karlin
Nov 8, 2008·Science in China. Series C, Life Sciences·Weifeng ShiChaodong Zhu
May 6, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Walter M BoyceCarol Cardona
Jul 14, 2009·Genomics, Proteomics & Bioinformatics·Venkata R S K DuvvuriJianhong Wu
May 15, 2007·Avian Diseases·Massimo CiccozziLaura Campitelli
Jul 5, 2006·Molecular Biology and Evolution·Yoshiyuki Suzuki
May 28, 2009·Science in China. Series C, Life Sciences·Di LiuGeorge Fu Gao
Jul 7, 2018·Journal of Veterinary Research·Edyta Świętoń, Krzysztof Śmietanka

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