Habitual dietary intake and mediators of the inflammaging process in Brazilian older women

Aging Clinical and Experimental Research
Roberta S PaulaOtávio T Nóbrega

Abstract

This study aimed to assess whether the habitual intake of macronutrients by older women associates with circulating levels of important inflammaging mediators by means of a cross-sectional design with 229 Brazilian elderly women. Laboratory tests determined serum IL1α, IL1β, IL6, IL8, IL10, IL12 and TNFα by specific immunoassays. Food records of three alternate days were decomposed into usual intake of carbohydrates, proteins and lipids (and fractions), as well as total energy value (TEV) per patient. Moreover, the study has identified and controlled results for metabolic conditions known to influence the inflammatory profile: hypercholesterolemia, hypertension and diabetes. Pearson's correlation test revealed that log10IL8 expressed a positive association with levels of saturated fatty acid (FA) (r = 0.173; p = 0.009) and total cholesterol intake (r = 0.223; p = 0.001). Similar analysis of the other mediators revealed no association with dietary intake. Higher intakes of total cholesterol and saturated FA seem to correlate with increased serum IL8 levels, being a possible mechanism by which this pro-atherogenic intake pattern may increase the risk of age-related chronic diseases with important inflammatory contribution.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 2, 1995·BMJ : British Medical Journal·A TrichopoulouD Trichopoulos
Jun 11, 1999·Journal of the American Dietetic Association·P S HainesB M Popkin
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Nov 4, 2000·The American Journal of Clinical Nutrition·M L McCulloughW C Willett
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 30, 2002·Journal of the American College of Cardiology·Francesco NappoDario Giugliano
Jun 27, 2003·The New England Journal of Medicine·Antonia TrichopoulouDimitrios Trichopoulos
Jun 26, 2004·Circulation Research·Rinky BhatiaCharles J Lowenstein
Jul 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kenji MatsushitaCharles J Lowenstein
Feb 23, 2005·Nutrition·Brian J WellsCharles J Everett
Apr 9, 2005·The American Journal of Clinical Nutrition·Tobias PischonEric B Rimm
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Jan 31, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·Patrícia Constante JaimeCristiano Augusto de Freitas Zerbini
Sep 30, 2008·Arquivos brasileiros de endocrinologia e metabologia·Júnia M Geraldo, Rita de C G Alfenas
Jul 28, 2009·Metabolism: Clinical and Experimental·James M ShikanyBarbara A Gower
Sep 11, 2009·Geriatrics & Gerontology International·Otávio T NóbregaJosé L Telles
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Dec 3, 2014·Archives of Gerontology and Geriatrics·Alause Silva PiresOtávio Toledo Nóbrega
Apr 24, 2015·Public Health Nutrition·Rita A G SouzaRosangela A Pereira

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Citations

Mar 5, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E S AlvesO T Nóbrega

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