Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Belinda M BrownDominantly Inherited Alzheimer Network

Abstract

The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression. No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

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Citations

Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Kristian Steen FrederiksenSteen Gregers Hasselbalch
Aug 30, 2018·International Journal of Geriatric Psychiatry·Nicola VeronesePinar Soysal
Sep 30, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Stephan MüllerUNKNOWN Dominantly Inherited Alzheimer Network (DIAN)
Dec 20, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ara S Khachaturian
Sep 17, 2019·American Journal of Lifestyle Medicine·Dean Sherzai, Ayesha Sherzai
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Stephanie J B Vos, Pieter Jelle Visser
Jun 15, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kristian S FrederiksenIan Law
May 8, 2020·Journal of Medical Internet Research·Anthoula C TsolakiPanagiotis D Bamidis
Aug 8, 2020·Neurology·Julie GonneaudUNKNOWN DIAN Study Group and the PREVENT-AD Research Group
Jun 21, 2020·Ageing Research Reviews·Pedro L ValenzuelaAlejandro Lucia
Apr 24, 2020·Neuroscience and Biobehavioral Reviews·Paula Iso-MarkkuIna M Tarkka
May 7, 2021·Journal of the International Neuropsychological Society : JINS·Jill N BarnesKathleen B Miller
Aug 15, 2021·Translational Neurodegeneration·Miao XuNan-Jie Xu

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