Abstract
The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression. No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.
References
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Aug 12, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe VerdileRalph N Martins
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Robert D AbbottHelen Petrovitch
Mar 16, 2005·Cell·Orly LazarovSangram S Sisodia
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul A AdlardCarl W Cotman
Oct 22, 2005·Lancet Neurology·Suvi RovioMiia Kivipelto
Apr 11, 2008·Journal of Neuroinflammation·Kathryn E NicholCarl W Cotman
Jun 16, 2009·Neurobiology of Disease·Carla M YuedeJohn G Csernansky
Aug 13, 2009·JAMA : the Journal of the American Medical Association·Nikolaos ScarmeasYaakov Stern
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nikolaos ScarmeasYaakov Stern
Sep 8, 2010·Annals of Neurology·Kelvin Y LiangDenise Head
Jan 5, 2011·Nature Reviews. Neuroscience·Lars M Ittner, Jürgen Götz
Jun 23, 2011·Medicine and Science in Sports and Exercise·Carol Ewing GarberUNKNOWN American College of Sports Medicine
Jan 11, 2012·Archives of Neurology·Denise HeadJohn C Morris
Apr 21, 2012·Neurology·A S BuchmanD A Bennett
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Aug 15, 2012·Molecular Psychiatry·B M BrownR N Martins
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Aug 24, 2013·Behavioural Brain Research·Hui-li LiuLi-de Shi
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tammie L S BenzingerJohn C Morris
Mar 7, 2014·Science Translational Medicine·Anne M FaganUNKNOWN Dominantly Inherited Alzheimer Network
Dec 9, 2014·NeuroImage·Yi SuUNKNOWN Dominantly Inherited Alzheimer Network
Mar 11, 2015·Current Biology : CB·Masashi TabuchiMark N Wu
Apr 29, 2015·Neuroscience·G ZhaoX J Tong
Nov 14, 2015·Neurobiology of Disease·Kaitlin M MooreBenjamin F Timson
Jul 12, 2016·Annals of Neurology·Andrei G VlassenkoAnne M Fagan
Citations
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Kristian Steen FrederiksenSteen Gregers Hasselbalch
Aug 30, 2018·International Journal of Geriatric Psychiatry·Nicola VeronesePinar Soysal
Sep 30, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Stephan MüllerUNKNOWN Dominantly Inherited Alzheimer Network (DIAN)
Dec 20, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ara S Khachaturian
Jan 23, 2020·Neurology·Eider M Arenaza-UrquijoPrashanthi Vemuri
Sep 17, 2019·American Journal of Lifestyle Medicine·Dean Sherzai, Ayesha Sherzai
Oct 2, 2020·Cells·Oliver K FullerMark A Febbraio
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Stephanie J B Vos, Pieter Jelle Visser
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Ralph N MartinsColin L Masters
Jun 15, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kristian S FrederiksenIan Law
May 24, 2020·Journal of Alzheimer's Disease : JAD·Priya PaltaRebecca F Gottesman
May 8, 2020·Journal of Medical Internet Research·Anthoula C TsolakiPanagiotis D Bamidis
Oct 26, 2018·Frontiers in Behavioral Neuroscience·Adrienne M GrechRachel A Hill
Aug 8, 2020·Neurology·Julie GonneaudUNKNOWN DIAN Study Group and the PREVENT-AD Research Group
Jan 15, 2021·PloS One·Eric D VidoniJeffrey M Burns
Jun 21, 2020·Ageing Research Reviews·Pedro L ValenzuelaAlejandro Lucia
Apr 2, 2020·Biological Psychiatry·Alexa Pichet BinetteUNKNOWN PREVENT-AD Research Group
Apr 24, 2020·Neuroscience and Biobehavioral Reviews·Paula Iso-MarkkuIna M Tarkka
May 7, 2021·Journal of the International Neuropsychological Society : JINS·Jill N BarnesKathleen B Miller
Aug 15, 2021·Translational Neurodegeneration·Miao XuNan-Jie Xu
Jul 7, 2021·Journal of Clinical Nursing·Pi-Chu LinKath Peters
Oct 26, 2021·Frontiers in Aging Neuroscience·Fang YuClifford Jack