Habitual long-distance running does not enhance urinary excretion of 8-hydroxydeoxyguanosine

European Journal of Applied Physiology and Occupational Physiology
A PilgerH W Rüdiger

Abstract

The energy demand during physical exercise causes an increased oxygen uptake and supply to active tissues, which may increase the rate of free oxygen radical production and thereby affect the capacity of endogenous cellular defense systems. This could result in DNA base modifications, among which 8-hydroxydeoxyguanosine (8OHdG) is one of the most important and has widely been used as a biomarker of in vivo oxidative lesions. Therefore, we examined the effect of regular running exercise on the urinary levels of 8OHdG in 32 long-distance runners and in a group of untrained healthy subjects. The range of 8OHdG in urine was 0.12-6.45 mumol/mol creatinine in both groups, and no significant difference in the mean excretion levels between runners and control probands was observed. This gives no reason to believe that physical exercise in trained individuals may induce a disturbance of the oxidant-to-antioxidant balance.

Citations

Jun 6, 2003·Free Radical Biology & Medicine·Jennifer M SacheckJeffrey B Blumberg
Oct 31, 2001·Nutrition·J M Sacheck, J B Blumberg
Mar 20, 2015·Free Radical Research·D VillañoA Gil-Izquierdo
Jul 31, 1998·Free Radical Research·J A DruryR W Cooke
Aug 25, 2009·Mutation Research·Stefanie ReichholdKarl-Heinz Wagner
Jul 29, 2011·Annals of the New York Academy of Sciences·Karl-Heinz WagnerOliver Neubauer
May 19, 2000·The Proceedings of the Nutrition Society·H E PoulsenS Loft

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