Hadamard editing of glutathione and macromolecule-suppressed GABA

NMR in Biomedicine
Georg OeltzschnerRichard A E Edden

Abstract

The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) and the major antioxidant glutathione (GSH) are compounds of high importance for the function and integrity of the human brain. In this study, a method for simultaneous J-difference spectral-edited magnetic resonance spectroscopy (MRS) of GSH and GABA with suppression of macromolecular (MM) signals at 3 T is proposed. MM-suppressed Hadamard encoding and reconstruction of MEGA (Mescher-Garwood)-edited spectroscopy (HERMES) consists of four sub-experiments (TE = 80 ms), with 20-ms editing pulses applied at: (A) 4.56 and 1.9 ppm; (B) 4.56 and 1.5 ppm; (C) 1.9 ppm; and (D) 1.5 ppm. One Hadamard combination (A + B - C - D) yields GSH-edited spectra, and another (A - B + C - D) yields GABA-edited spectra, with symmetric suppression of the co-edited MM signal. MM-suppressed HERMES, conventional HERMES and separate Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) data were successfully acquired from a (33 mm)3 voxel in the parietal lobe in 10 healthy subjects. GSH- and GABA-edited MM-suppressed HERMES spectra were in close agreement with the respective MEGA-PRESS spectra. Mean GABA (and GSH) estimates were 1.10 ± 0.15 i.u. (0.59 ± 0.12 i.u.) for MM-suppressed HE...Continue Reading

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Apr 30, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark MikkelsenC John Evans
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Dec 31, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin SimpsonJamie Near
Apr 20, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kimberly L ChanRichard A E Edden
May 31, 2016·Journal of Magnetic Resonance Imaging : JMRI·Richard A E EddenPeter B Barker
Aug 19, 2016·NeuroImage·Muhammad G SalehRichard A E Edden
Nov 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Georg OeltzschnerRichard A E Edden

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Citations

Feb 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kimberly L ChanPeter B Barker
Apr 18, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Muhammad G SalehThomas Ernst
Jan 17, 2020·NMR in Biomedicine·Muhammad G SalehEric C Porges
Sep 19, 2020·NMR in Biomedicine·In-Young ChoiRobin A de Graaf
Oct 8, 2021·Molecular Autism·Laurie-Anne Sapey-TriompheJohan Wagemans
Oct 17, 2021·Neuroradiology·Yulu SongRichard A E Edden

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