Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus.

Immunology
Andrés A HerradaAlexis M Kalergis

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple functional alterations affecting immune cells, such as B cells, T cells, dendritic cells (DCs) and monocytes. During SLE, the immunogenicity of monocytes and DCs is significantly up-regulated, promoting the activation of self-reactive T cells. Accordingly, it is important to understand the contribution of these cells to the pathogenesis of SLE and the mechanisms responsible for their altered functionality during disease. One of the key enzymes that control monocyte and DC function is haem oxygenase-1 (HO-1), which catalyses the degradation of the haem group into biliverdin, carbon monoxide and free iron. These products possess immunosuppressive and anti-inflammatory capacities. The main goal of this work was to determine HO-1 expression in monocytes and DCs from patients with SLE and healthy controls. Hence, peripheral blood mononuclear cells were obtained from 43 patients with SLE and 30 healthy controls. CD14(+) monocytes and CD4(+) T cells were sorted by FACS and HO-1 expression was measured by RT-PCR. In addition, HO-1 protein expression was determined by FACS. HO-1 levels in monocytes were significantly reduced in patients with SLE compar...Continue Reading

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Citations

May 14, 2014·Inflammation·Bao-Zhu LiDong-Qing Ye
Jul 16, 2015·Immunology·Juan P Mackern-ObertiAlexis M Kalergis
May 23, 2013·Immunology·Juan P Mackern-ObertiAlexis M Kalergis
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Feb 20, 2018·Immunology·Samanta C FunesAlexis M Kalergis
Sep 12, 2019·Immunology·Samanta C FunesAlexis M Kalergis
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Aug 28, 2020·Frontiers in Immunology·Samanta C FunesAlexis M Kalergis
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May 1, 2019·Frontiers in Immunology·Andrés A HerradaCarolina Llanos
Jun 13, 2020·Seminars in Arthritis and Rheumatism·Shiva GanjaliAmirhossein Sahebkar
Apr 1, 2021·Cellular and Molecular Life Sciences : CMLS·Agata SzadeAlicja Józkowicz

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