PMID: 2098701Oct 1, 1990Paper

Haemagglutinating and haemolytic activity of the extracellular vesicles of Bacteroides gingivalis W50

Oral Microbiology and Immunology
H M KayJ W Smalley

Abstract

The extracellular vesicles (ECV) and extracellular protein (EP) fractions of Bacteroides gingivalis W50 showed haemagglutinating (HA) activity towards sheep erythrocytes. Similar fractions from the nonpathogenic strain W50/BE1 did not haemagglutinate. W50 ECV HA activity was not inhibited by various glycosidase, phospholipase or protease pretreatments, sugars or amino acids, including arginine or lysine. The haemagglutinating activity of ECV was associated only with the extracellular vesicle membrane. The EP and ECV of both strains displayed haemolytic activity. This activity was apparently depressed in the presence of 10 mM dithiothreitol (DTT). All EP and ECV fractions degraded certain structural sheep erythrocyte membrane proteins. The greatest activity was displayed by W50 ECV and W50/BE1 EP and was enhanced by DTT. In the presence of DTT, the ECV of both strains degraded purified human haemoglobin but this activity was greatly reduced in its absence.

References

Jan 1, 1976·Annual Review of Biochemistry·V T MarchesiM Tomita
Sep 1, 1988·Journal of Medical Microbiology·A S McKeeP D Marsh
May 1, 1974·Archives of Oral Biology·K Okuda, I Takazoe
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Citations

Jul 15, 1996·FEMS Microbiology Letters·J W SmalleyP D Marsh
Jul 31, 1999·FEMS Microbiology Letters·R G Deshpande, M B Khan
Dec 15, 1993·FEMS Microbiology Letters·M HoshiK Hasegawa
Jan 12, 2001·Oral Microbiology and Immunology·E NagaoR Sasa
Jan 18, 2005·FEMS Microbiology Reviews·Teresa OlczakCaroline Attardo Genco
Jun 26, 2003·Oral Microbiology and Immunology·L KesavaluJ L Ebersole
Jan 1, 1995·FEMS Immunology and Medical Microbiology·S FujimuraT Nakamura
Mar 1, 1997·Journal of Bacteriology·T KarunakaranH Kuramitsu
Apr 1, 1992·Infection and Immunity·J ZwickelA Schejter

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