PMID: 6164249Dec 1, 1980Paper

Haemagglutination-inhibition antibodies in human sera to an antigenic mutant of influenza A/Texas/1/77 (H3N2) virus obtained in vitro

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
L R Haaheim

Abstract

An antigenic mutant of the wild influenza strain A/Texas/1/77 (H3N2) was obtained in vitro by growing virus of the allantosis-on-shell system in the presence of a mouse monoclonal antibody preparation to the Texas haemagglutinin (HA) antigen. A total of 204 human sera, from a population of randomly collected sera during the fall of 1979, were examined by the haemagglutination-inhibition (HI) tests against the Texas wild strain and the antigenic mutant. It was shown that sera from young children (0-5 years) reacted poorly, or not at all, with this mutant strain, whereas sera from adults (15 years +) reacted equally well with both viruses. It can be assumed that the antigenic site recognised by this particular monoclonal antibody preparation (185/1) may be important for the human immune response to the HA antigen of A/Texas/1/77 virus.

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiC M Croce
Jan 1, 1979·British Medical Bulletin·J L VirelizierG C Schild
Jul 1, 1976·European Journal of Immunology·G Köhler, C Milstein
Apr 1, 1972·The Journal of General Virology·D McCahon, G C Schild
Mar 1, 1958·The Journal of Hygiene·S FAZEKAS DE ST GROTH, D O WHITE

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