Haemangiopericytoma of the thyroid gland in combination with Hashimoto's disease

Virchows Archiv : an International Journal of Pathology
T HansenC J Kirkpatrick

Abstract

We present a hitherto unique case of haemangiopericytoma (HP) of the thyroid gland in a 15-year-old female patient suffering from Hashimoto's disease for several months. Since angiogenesis has been discussed to play a major role in both diseases, we examined the expression of vascular endothelial growth factor (VEGF), VEGF receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs). Most interestingly, strong expression of PDGFR alpha and beta was found in spindle-shaped tumour cells and tumour vessels in HP, while VEGF and VEGFR type I and -II were negative in these regions. In contrast, VEGF was expressed in the lymphoid infiltrate of Hashimoto's disease. Since PDGFR-beta is commonly expressed in pericytes, we suggest that the strong expression discovered in this study further supports the view that HP is derived from pericytes. The combination of HP and Hashimoto's disease is most probably a coincidental event. However, this case confirms previous reports demonstrating that in patients with Hashimoto's disease different neoplasias can occur.

References

Oct 13, 1998·Virchows Archiv : an International Journal of Pathology·M MiettinenA J Kovatich
May 18, 2001·British Journal of Cancer·M A KonerdingA Gaumann
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Renhai CaoYuhai Cao
Sep 27, 2003·Histopathology·J Cameselle-TeijeiroM Sobrinho-Simões
Oct 17, 2003·The Journal of Clinical Investigation·Alexandra AbramssonChrister Betsholtz
Dec 5, 2003·Leukemia Research·Adila El-ObeidKishor Bhatia
Jul 1, 1942·Annals of Surgery·A P Stout, M R Murray

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Citations

Jul 29, 2006·Pathology International·Jin TanahashiShigeo Yokoyama
Nov 6, 2020·The Lancet Oncology·Sriram GubbiJoanna Klubo-Gwiezdzinska

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