Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients

British Journal of Haematology
Steven H KroftNitin J Karandikar

Abstract

Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 x 10(9)/l (median 0.0054 x 10(9)/l, mean 0.012 x 10(9)/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.

References

Oct 1, 1988·Immunology and Cell Biology·K F BradstockC Luxford
Nov 20, 1998·Cytometry·M R O'GormanR Yogev
Dec 22, 1999·British Journal of Haematology·K A BradyC A Lowell

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Citations

Mar 30, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Huan-You WangNitin J Karandikar
Jun 16, 2012·Acta Haematologica·Oluyomi E Kabiawu-AjiseSherif Ibrahim
Jul 16, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Tajana JuranovicTomislav M Jelic
May 3, 2008·Leukemia & Lymphoma·Ol'ga BabusíkováEsko Kankuri
Dec 17, 2009·Leukemia & Lymphoma·Deborah W SevillaBachir Alobeid
Nov 21, 2009·American Journal of Clinical Pathology·Adam C SeegmillerRobert W McKenna
Jan 11, 2007·American Journal of Clinical Pathology·Adam C SeegmillerNitin J Karandikar
Mar 10, 2005·British Journal of Haematology·Lawrence TsaoBachir Alobeid
Aug 13, 2013·Leukemia Research·S P ChantepieO Reman
May 29, 2018·Journal of Clinical Pathology·Jason H Kurzer, Olga K Weinberg
Dec 15, 2018·Cytometry. Part B, Clinical Cytometry·Adam C SeegmillerFiona E Craig

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