PMID: 25786696DOI: 10.1038/nrc3907Mar 20, 2015Paper
Haematological malignancies: at the forefront of immunotherapeutic innovation
Nature Reviews. Cancer
Pavan BachireddyCatherine J Wu
Abstract
The recent successes of cancer immunotherapies have stimulated interest in the potential widespread application of these approaches; haematological malignancies have provided both initial proofs of concept and an informative testing ground for various immune-based therapeutics. The immune-cell origin of many of the blood malignancies provides a unique opportunity both to understand the mechanisms of cancer immune responsiveness and immune evasion, and to exploit these mechanisms for therapeutic purposes.
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