Haematological, serum electrolyte and blood gas effects of small volume hypertonic saline in experimentally induced haemorrhagic shock

Equine Veterinary Journal
L M SchmallJ T Robertson

Abstract

The effects of treatment with small volume hypertonic (2400 mOsm/litre) and isotonic (300 mOsm/litre) saline on serum electrolyte and biochemical concentrations, haemograms and blood gases were evaluated in 12 horses using a haemorrhagic shock model. Intravascular catheters were placed surgically for sample collection prior to anaesthesia. Controlled haemorrhage was initiated and continued until mean systemic pressure reached 50 to 60 mmHg. Hypertonic or isotonic saline (2 litres) was administered by intravenous infusion and data collected for 2 h. Following haemorrhage, packed cell volume (PCV), haemoglobin, blood glucose concentrations and erythrocyte numbers increased whereas plasma total protein and albumin concentrations decreased. Infusion of hypertonic saline resulted in a further decrease in total protein and albumin concentrations. Glucose concentrations and other haematological variables were unaffected. Isotonic saline administration did not affect electrolyte, total protein or albumin concentrations. Concentrations of sodium and chloride were unaffected by hypotension but increased significantly following hypertonic saline treatment, exceeding normal values during the immediate post treatment period. Serum osmolalit...Continue Reading

References

Dec 1, 1985·The Journal of Surgical Research·G J SmithJ W Holcroft

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Citations

Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Lindsey B C Snyder, Erin Wendt-Hornickle
Aug 28, 2010·Critical Care Medicine·Shelly D Timmons
Aug 19, 2015·Equine Veterinary Journal·H TavanaeimaneshK T T Corley
Mar 11, 2015·Journal of Veterinary Emergency and Critical Care·Cristobal Navas de SolisJoAnn Slack
Nov 3, 2006·Journal of the American Veterinary Medical Association·K Gary MagdesianRebecca E Ruby
Apr 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·F GasthuysA De Moor

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