PMID: 6968866Sep 18, 1980Paper

Haematopoietic growth factors are released in cultures of H-2-restricted helper T cells, accessory cells and specific antigen

Nature
M H Schreier, N N Iscove

Abstract

Colony formation by mammalian haematopoietic cells in culture depends on specific glycoprotein growth factors. 'Colony-stimulating factors' for granulocytic and macrophage precursors (G- and M-CSFs), as well as for pluripotential and early committed erythroid cells ('burst promoting activity, or BPA) are released in cultures of stimulated spleen, lymph node or peripheral blood cells. In such systems the induction stimulus has been either allogenic cell antigens, or lectins which stimulate T cells, such as pokeweed mitogen, concanavalin A (Con A) or phytohaemagglutin and both T cells and adherent cells are implicated in the process. The complexity of the spleen cell populations used in earlier in vitro studies has made it difficult to establish the cellular source of the factors and the mechanisms leading to their release. Pure populations of continuously growing cell lines of either monocytic/macrophage or T-cell character have already been shown to release haematopoietic activities constitutively. However, such evidence cannot prove that these functions are also expressed by the normal counterparts of these lines. We have reduced the complexity of the spleen cell system by supplying helper T cells in the form of pure clonal po...Continue Reading

References

Feb 1, 1978·The Journal of Experimental Medicine·D G NathanD E Housman
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E R Stanley
Oct 1, 1974·Journal of Cellular Physiology·D MetcalfP W Kincade
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Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Mar 1, 1982·Immunobiology·M H SchreierM J van Zwieten
Jul 2, 1981·The New England Journal of Medicine·J H FitchenM J Cline
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J PaigeC L Sidman
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Donald MetcalfSandra Mifsud
May 1, 1980·Molecular Immunology·K A SmithF W Ruscetti
Jul 1, 1983·Annales d'immunologie·F Melchers, C Corbel
Jan 1, 1986·Critical Reviews in Oncology/hematology·C A Sieff
Oct 1, 1983·Experimental Parasitology·G MungyerR Jerusalem
Jul 1, 1982·British Journal of Haematology·C NissenB Speck
Jan 1, 1982·Journal of Cellular Biochemistry·F MelchersJ Zeuthen
Dec 1, 1987·Immunological Reviews·W L FarrarM Vinocour
Apr 1, 1985·Journal of Cellular Physiology·A Kelso, D Metcalf
Mar 1, 1983·British Journal of Haematology·J M Lipton, D G Nathan
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner
Jan 1, 1982·Journal of Cellular Physiology. Supplement·F Melchers
Jan 1, 1987·Critical Reviews in Oncology/hematology·G TrinchieriB Perussia

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