Haematopoietic transplant potential of unrelated and related cord blood: the first six years of the EUROCORD/NETCORD Bank Germany

Klinische Pädiatrie
G KöglerP Wernet


To date, human umbilical cord blood (CB) has been employed successfully in well over 1000 allogeneic (unrelated and sibling) stem cell transplantations. Because of primary limitations in volume and cell numbers, over 90% of these transplantations were performed in children. Therefore requests for well standardised cord blood units of high quality are now increasing constantly. Examination and standardisation of unrelated and related cord blood stem cell preparations and banking as well as their biological characterisation was already initiated in Düsseldorf in 1992. Hitherto a total of 3236 CB samples with a mean volume of 89 +/- 25 ml, a mean total number of nucleated cells (NC) of 10 +/- 5 x 10(8) and a mean number of CFU-GM of 6 +/- 5 x 10(5) have also been validated by haematological, immunological and microbiological criteria. In addition to that, 97 directed CB donations of siblings with a clinical indication have been characterised and banked along the same lines. All CB units were collected from the umbilical cord vein immediately after vaginal full term delivery or caesarean section, then frozen and stored in liquid nitrogen. 1940 CB units were stored unseparated, the other 1296 were volume reduced using Hetastarch (HE...Continue Reading


Jun 16, 2001·The New England Journal of Medicine·E Gluckman
May 3, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Thomas BartRudolf Schwabe
Mar 23, 2010·Transfusion Medicine Reviews·Ronald G Strauss, John A Widness
Apr 17, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·J Garcia
Dec 13, 2005·Annals of the New York Academy of Sciences·Mark C WaltersBert Lubin
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V AdamiC Pipan
Feb 22, 2002·Vox Sanguinis·A HonohanA Brand
Jan 29, 2005·Blood·Karen K Ballen
Mar 3, 2012·The Journal of Obstetrics and Gynaecology Research·Fadilah S Abdul WahidZaleha Abdullah Mahdy

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