Haemodialysis in massive caffeine intoxication

Clinical Kidney Journal
Kathrin FauschAndreas Pasch

Abstract

Caffeine is the most widely consumed psychoactive substance worldwide. Intoxication causes central nervous system and haemodynamic complications, which have significant mortality rates. We report the case of a 39-year-old woman who ingested ∼0.5 mol (100 g) of pure caffeine, leading to a peak serum concentration of 2.95 mmol/L (574 mg/L). Three consecutive haemodialysis sessions caused serum caffeine reduction rates of 66, 46 and 45%, indicating that the unbound caffeine fraction is not dose linear in this high serum caffeine concentration range. Aggressive and repeated haemodialysis sessions may be of benefit in cases of severe caffeine intoxication.

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Citations

Feb 16, 2016·British Journal of Hospital Medicine·Jane L GibsonHamish Walker
Dec 3, 2014·Internal Medicine·Sayaka IshigakiRyuichi Furuya
Oct 1, 2020·Acute Medicine & Surgery·Tomoatsu TsujiSadaki Inokuchi
Apr 23, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Apr 15, 2021·Kidney Medicine·Mohamed ElboklCharmaine Lok

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