PMID: 6982745Nov 1, 1982Paper

Haemodynamic and catecholamine response to isoflurane anaesthesia in patients undergoing coronary artery surgery

Canadian Anaesthetists' Society Journal
K BalasarawathiN Mummaneni

Abstract

Haemodynamic and plasma catecholamine responses were evaluated during isoflurane anaesthesia in ten patients undergoing coronary artery bypass surgery. Following thiopentone induction the patients were anaesthetized with isoflurane 1.5-2.0 per cent in oxygen. The results show that after 10 minutes of isoflurane anaesthesia there was a significant increase from baseline in heart rate, 68 to 80; cardiac output, 3.75 to 4.61; and plasma epinephrine, 0.80 to 1.33 microgram/l. Conversely, there was a significant reduction in systemic vascular resistance index, 3388 to 2260, and plasma norepinephrine, 1.10 to 0.88 microgram/l. Twenty-five minutes later, after sternotomy, heart rate, cardiac output and the level of plasma epinephrine were still elevated, and systemic vascular resistance index and plasma norepinephrine remained lowered (p less than 0.05). This study demonstrates significant catecholamine responses during isoflurane anaesthesia. The increase in plasma epinephrine parallelled the increase in heart rate and cardiac output, and the decrease in plasma norepinephrine paralleled the decrease in systemic vascular resistance. Based upon these findings we conclude that catecholamine responses contribute to the cardiac and periph...Continue Reading

References

May 1, 1978·Canadian Anaesthetists' Society Journal·K BalasaraswathiR Pifarre
May 1, 1977·Canadian Anaesthetists' Society Journal·P Skovsted, S Sapthavichaikul
Nov 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J B HalterD Porte
Nov 1, 1974·Anesthesiology·M F RoizenI J Kopin
Nov 1, 1974·Anesthesiology·C L GravesA Bidwai
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·S Takki, T Tammisto
Jan 1, 1971·British Journal of Anaesthesia·T Tammisto, S Takki
Jan 1, 1972·Acta Anaesthesiologica Scandinavica·A B DobkinA A Levy
Nov 1, 1981·Anesthesiology·E I Eger
Mar 1, 1980·Canadian Anaesthetists' Society Journal·K BalasaraswathiC Azad

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Citations

Feb 1, 1991·Acta Anaesthesiologica Scandinavica·F TandonnetJ Truffa-Bachi
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·J M BernardJ V Bainvel
Nov 1, 2001·Journal of Cardiothoracic and Vascular Anesthesia·P HuJ Liu
Nov 1, 2001·Journal of Cardiothoracic and Vascular Anesthesia·J X Zhou, J Liu
Feb 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·Michelle A KeskeEtto C Eringa

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