PMID: 3030387Feb 1, 1987Paper

Haemodynamic and humoral effects of oral perindopril, an angiotensin converting enzyme inhibitor, in man

British Journal of Clinical Pharmacology
K R Lees, J L Reid

Abstract

The tolerance to and dynamic effects of 1 week's oral treatment with the angiotensin converting enzyme inhibitor, perindopril, were assessed in a placebo controlled, parallel group study in 36 normotensive males. The daily dose of perindopril was 1, 2, 4, 8 or 16 mg. The drug was well tolerated and produced no change in routine haematology or serum biochemistry tests. Dose related inhibition of plasma angiotensin converting enzyme was observed. Perindopril 16 mg produced 90% inhibition 4 h after dosing and 60% after 24 h. A dose related rise in plasma renin activity followed doses of 4 mg and over. The renin remained above the normal range for 24 h. Perindopril caused a modest lowering of plasma aldosterone levels but had no effect on plasma adrenaline or noradrenaline levels. Standing diastolic blood pressure was lowered, particularly with 16 mg daily of perindopril but only a slight rise in heart rate occurred. Perindopril appears to be a well tolerated inhibitor of plasma angiotensin converting enzyme, with predictable effects on the renin angiotensin system and blood pressure. An appropriate dose range for further study would appear to be 4 to 16 mg daily.

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Citations

Mar 1, 1992·British Journal of Clinical Pharmacology·M ThiolletP Jaillon
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·T Morgan, A Anderson
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·H Thurston
Nov 1, 1993·Clinical and Experimental Hypertension : CHE·P A van Zwieten
Oct 22, 2005·Journal of Clinical Pharmacology·Shuichi TsuruokaAkio Fujimura
Apr 27, 1992·The American Journal of Medicine·F GiuntoliP Saba
Apr 27, 1992·The American Journal of Medicine·E Agabiti-RoseiA C Pessina
Sep 7, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Petra NijstWilfried Mullens
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Roberto Ferrari
Jul 1, 1989·British Journal of Clinical Pharmacology·H H TsaiJ L Reid
Jun 12, 2001·Drugs·M Hurst, B Jarvis

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