Haemodynamic changes and vasopressin release are not consistently associated with carbon dioxide pneumoperitoneum in humans

Acta Anaesthesiologica Scandinavica
C LentschenerD Benhamou

Abstract

Conflicting haemodynamic changes, suggested to be caused by vasopressin release, have been reported during carbon dioxide (CO2) pneumoperitoneum. However, peritoneal stimulations including open surgery cause both a systemic vasopressor response and a vasopressin release, which are suppressed by opiate administration. Also, a decreased venous return of blood to the heart causes vasopressin release. Furthermore, previous haemodynamic assessments of laparoscopic surgery have been conducted using various anaesthetic regimens, which are likely to have caused various haemodynamic effects. We hypothesised that intraoperative haemodynamic and/or humoral changes would not be observed in association with laparoscopic surgery provided that, (a) normovolaemia is continuously maintained using transoesophageal echocardiographic (TEE) assessment, and (b) adequate depth of general anaesthesia is continuously maintained by bispectral index (BIS) monitoring and high plasma Ievel opiate administration. Twenty ASA 1 women undergoing laparoscopic surgery received 10 ml. kg-1 lactated Ringer's solution and thereafter were randomly allocated to receive intraoperatively either 8 ng. ml-1 or 4 ng. ml-1 plasma remifentanil concentrations while BIS was m...Continue Reading

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Citations

Jun 28, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·C BraumannT Junghans
Mar 22, 2003·Acta Anaesthesiologica Scandinavica·K MyreO Stokland
Jun 14, 2003·Acta Anaesthesiologica Scandinavica·C A GreimJ Schulte am Esch
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·K MyreO Stokland
Jul 15, 2017·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Yi ZhangJiefeng Zhang
Aug 12, 2004·British Journal of Anaesthesia·M Lippmann, C Kakazu

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