PMID: 9170341May 1, 1997Paper

Haemodynamic correlates of early and delayed responses to sublingual administration of isosorbide dinitrate in migraine patients: a transcranial Doppler study

Cephalalgia : an International Journal of Headache
P BellantonioG Nappi

Abstract

In normal subjects or migraine patients, nitrates induce a non-specific early headache caused by vasodilation of intracranial arteries. In migraineurs a delayed headache response to nitrates may have a typical clinical profile of a spontaneous migraine attack. The cerebral vasomotor changes of this delayed response require further study. Isosorbide dinitrate (IDN), an exogenous nitric oxide (NO) donor, was given at a dose of 5 mg sublingually and a bilateral transcranial Doppler device was used to monitor bilateral mean velocity (Vm) changes at the middle cerebral artery (MCA) after IDN administration and until delayed headache occurred. Spontaneous migraine-like headache occurred only in migraine patients during the delayed phase after IDN and was accompanied by a prolonged arterial vasodilation compared to normal subjects. This vasomotor response was more evident on the customary side of the head pain of a spontaneous migraine attack. Our findings suggest a particular vasomotor response to nitrates in migraine patients. This response is associated with the nitrate-induced headache and it is not evident in healthy pain-free controls during the delayed phase after administration of an NO donor. Owing to the short half-life of N...Continue Reading

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Citations

May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jes Olesen
Jun 17, 2006·Cephalalgia : an International Journal of Headache·G G SchoonmanR W Baumgartner
Feb 26, 2008·Cephalalgia : an International Journal of Headache·J M HansenM Ashina
Apr 4, 2008·Cephalalgia : an International Journal of Headache·J M HansenM Ashina
Sep 1, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jakob M Hansen, Christoph J Schankin
Mar 25, 2010·British Journal of Pharmacology·G BagdyG Juhász
May 24, 2001·Current Opinion in Neurology·L L Thomsen, J Olesen

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