PMID: 6167802Jul 1, 1981Paper

Haemodynamic dose-response effects of intravenous oxprenolol in coronary heart disease

Journal of Cardiovascular Pharmacology
B SilkeS H Taylor

Abstract

The haemodynamic dose-response effects of intravenous oxprenolol over the range of 2--64 mg were measured in 28 patients with coronary heart disease. At rest there were statistically significant dose-response trends, linear or quadratic, between the cumulative doses of oxprenolol and reductions in systolic pressure, heart rate, and cardiac output and increases in stroke volume and pulmonary wedge pressure. The magnitude of the changes was uninfluenced by the degree of left ventricular functional disability as judged by the level of the pulmonary wedge pressure. During dynamic exercise the haemodynamic changes induced by oxprenolol were significantly greater in patients with more marked left ventricular disability than in those less severely affected. These observations define the immediate effects of intravenous oxprenolol over a relatively wide dose range and confirm its relative haemodynamic safety in patients with stable coronary heart disease.

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·W G HendryS H Taylor
Jan 1, 1983·European Journal of Clinical Pharmacology·B SilkeS H Taylor
Feb 10, 2012·International Journal of Pediatrics·Michela PaolucciVittorio Sambri
Nov 1, 1983·British Journal of Clinical Pharmacology·B SilkeS H Taylor

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