PMID: 33811Feb 19, 1979

Haemodynamic effects and pharmacokinetics of a new selective beta1-adrenoceptor agonist, prenalterol, and its interaction with metoprolol in man

European Journal of Clinical Pharmacology
O RönnJ Wikstrand

Abstract

The haemodynamic effects of the selective beta1-adrenoceptor agonist prenalterol were studied in healthy subjects before and after therapeutic doses of the selective beta1-adrenoceptor blocker metoprolol. Plasma levels of the drugs were also determined in order to calculate certain pharmacokinetic variables. Intravenous infusion of prenalterol 0.13, 0.25 and 0.50 mg induced a dose-dependent decrease in total electromechanical systole (QA2) and pre-ejection period (PEP). The effect on left ventricular ejection time (LVET) was not significant. Increases in systolic blood pressure and heart rate were dose-dependent. Diastolic blood pressure did not change significantly. When metoprolol had been administered in a cumulative dose of 150 mg (mean maximal plasma level, 284 nmol/l) prenalterol had to be administered in doses that were twelve times higher than before the beta-blocker in order to induce the same haemodynamic effects. Prenalterol was rapidly distributed with an average half life of 8 min. This indicates that distribution equilibrium will be achieved within 30 min after intravenous administration. The overall elimination rate in the post-distributive phase corresponded to an average half life of 2.0 h.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
May 31, 1978·European Journal of Clinical Pharmacology·G JohnssonJ Wikstrand
Jul 1, 1976·Journal of Pharmaceutical Sciences·A J Sedman, J G Wagner
Apr 1, 1969·The American Journal of Cardiology·A M WeisslerC D Schoenfeld

Citations

Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·N RohmH J Schümann
Jan 1, 1983·European Journal of Clinical Pharmacology·D N Sharpe, R Coxon
Jan 1, 1985·European Journal of Clinical Pharmacology·E J SainsburyJ J Ashley
Oct 1, 1980·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Jan 1, 1981·European Journal of Clinical Pharmacology·C GraffnerO Rönn
Nov 1, 1980·European Journal of Clinical Pharmacology·A WeissU C Dubach
Mar 1, 1981·The American Journal of Cardiology·P C Kirlin, B Pitt
Jan 1, 1982·Pharmacology & Therapeutics·D B EvansH R Kaplan
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Jun 1, 1987·Acta Physiologica Scandinavica·B Wohlfart, A R Khan
Jan 1, 1983·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Apr 15, 1980·Klinische Wochenschrift·K A MeurerA Helber
Jun 1, 1982·Journal of Clinical and Hospital Pharmacy·M J KendallS Westerling
Jul 1, 1983·Medicinal Research Reviews·J A Bristol, D B Evans
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·P O Järnberg, L Westman
Jan 1, 1980·Acta Anaesthesiologica Scandinavica·S Reiz, A Friedman
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson
Jan 1, 1985·Acta Medica Scandinavica·K LindvallA Sjögren
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·R ErbelS Effert
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·G Johnsson
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·P C KirlinB R Lucchesi
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·A HedbergE Carlsson
Jun 1, 1992·Journal of Clinical Pharmacy and Therapeutics·C A Haffner, M J Kendall
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·D Oltmanns
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·G KleinC Graffner
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·W DoeringJ Isbary
Feb 1, 1984·Acta Pharmacologica Et Toxicologica·E S PlatouH Refsum
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·E N MooreG Adler
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H A Wester, D Oltmanns
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·E Lyrenäs

Related Concepts

Adrenergic beta-Agonists
Drug Interactions
Pulse Rate
Hemodynamics
Betalok
Propanolamines

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.