PMID: 1203917Nov 1, 1975Paper

Haemodynamic effects of a new anti-arrhythmic agent, mexiletine (Kö 1173) in ischaemic heart disease

Cardiovascular Research
Saunamäki

Abstract

The haemodynamic effects of mexiletine (Kö 1173) were studied in six patients. Heart rate and cardiac output remained unchanged. The systemic arterial pressure was reduced in two patients owing to a fall in the peripheral resistance. Cardiac function, assessed by means of the stroke work and pulmonary capillary wedge pressure, was depressed in three patients, who all had a current or past history of severe heart failure.

Citations

May 1, 1990·Clinical Cardiology·A S ManolisN A Estes
Jul 1, 1978·British Heart Journal·N P CampbellA A Adgey
Feb 1, 1979·British Heart Journal·N P CampbellJ F Pantridge
Sep 22, 1983·The American Journal of Cardiology·P J Block, R A Winkle
Feb 20, 1990·The American Journal of Cardiology·P J Podrid, S L Beau
Jan 1, 1987·The New England Journal of Medicine·R W Campbell

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