PMID: 39584Aug 1, 1979

Haemodynamic effects of a new beta 1-receptor agonist in acute myocardial infarction. A useful antidote to unwanted cardiac effects of beta-blocking agents

British Heart Journal
R AriniegoA C Hjalmarson

Abstract

The haemodynamic effects of a new beta 1-receptor agonist, 1-(4 hydroxyphenoxy) 3-isopropylamino-2-propanol, were studied in 25 patients after acute myocardial infarction using non-invasive methods. The drug caused an increase in systolic blood pressure and pulse pressure, without change in diastolic blood pressure, and a slight increase in heart rate and reduction in the pre-ejection period. These changes were greater in patients without a history of left heart failure. It is suggested that this cardioselective drug possesses positive inotropic activity but only slight positive chronotropic activity. The substance has been further investigated as a possible antidote to unwanted cardiac side effects of the cardioselective beta-blocker, metoprolol. The changes in the cardiovascular dynamics caused by metoprolol in patients with acute myocardial infarction were promptly reversed by this new beta 1-agonist. With its positive inotropic properties and its efficacy in reversing the effects of a cardioselective beta-blocker, the drug is a potentially useful pharmacological agent to support an acutely depressed myocardium in patients on beta-blocking agents.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
Jun 1, 1978·British Journal of Clinical Pharmacology·F WaagsteinA C Hjalmarson
Nov 23, 1976·The American Journal of Cardiology·H K GoldP R Maroko
Aug 1, 1975·British Heart Journal·C F GeorgeA Petrie
Aug 1, 1975·The American Journal of Cardiology·N AkhtarM H Chaudhry
Jan 1, 1974·Progress in Cardiovascular Diseases·D E Jewitt, B N Singh
Feb 1, 1971·The American Journal of Cardiology·E D Frohlich
May 1, 1974·Circulation Research·N W RobieJ L McNay
Jul 1, 1972·British Heart Journal·J BeregovichA Grishman
Nov 1, 1972·Circulation·J VidebaekB Sterndorff

Citations

Oct 1, 1980·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Nov 1, 1980·European Journal of Clinical Pharmacology·A WeissU C Dubach
Mar 1, 1981·The American Journal of Cardiology·P C Kirlin, B Pitt
Jan 1, 1983·Intensive Care Medicine·R Hayward
Jan 1, 1985·American Heart Journal·E FelekeS Westerling
Jun 1, 1983·Acta Anaesthesiologica Scandinavica·H Tydén, S O Nyström
Jun 1, 1982·Journal of Clinical and Hospital Pharmacy·M J KendallS Westerling
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·H TydénS O Nyström
Jan 1, 1980·Acta Anaesthesiologica Scandinavica·S Reiz, A Friedman
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·L EkB Johansson
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·P C KirlinB R Lucchesi
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H A Wester, D Oltmanns
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·F WaagsteinA C Hjalmarson
Feb 1, 1984·Acta Pharmacologica Et Toxicologica·E S PlatouH Refsum
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·D Oltmanns
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H MattssonE Carlsson
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·K E Andersson
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·A C HjalmarsonM Estrada-Yamamoto
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·T AnderssonH Mattsson
Jan 1, 1985·Acta Medica Scandinavica·K LindvallA Sjögren
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson

Related Concepts

Acute Disease
Adrenergic beta-Agonists
Heart
Pulse Rate
Hemodynamics
Betalok
Myocardial Contraction
Myocardial Infarction
Propanolamines

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