Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction

European Journal of Heart Failure
Federico MiglioreGiuseppe Tarantini

Abstract

Takotsubo syndrome, also called apical ballooning syndrome, is a clinical entity characterized by transient hypokinesis, akinesis, or dyskinesis of the left ventricular mid-segments with or without apical involvement, and without obstructive coronary lesions. The contemporary presence of left ventricular outflow tract obstruction (LVOTO), systolic anterior motion of the anterior mitral leaflet, and acute mitral regurgitation might explain the worsening of the heart failure or the occurrence of cardiogenic shock in some patients with apical ballooning syndrome. The use of beta-blockers should improve the LVOTO gradient by reducing basal hypercontractility, increasing left ventricular filling and size, and reducing heart rate. However, clear evidence of the direct haemodynamic effects of beta-blockers is still lacking. We present a case of apical ballooning syndrome complicated by dynamic LVOTO, treated with metoprolol.

References

Dec 25, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Michifumi KyumaKazuaki Shimamoto
Sep 2, 2008·American Heart Journal·Rami El MahmoudOlivier Dubourg

❮ Previous
Next ❯

Citations

Jan 1, 2013·Global Cardiology Science & Practice·Veronica SpadottoMartina Perazzolo Marra
Apr 15, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Efrén Martínez-QuintanaFayna Rodríguez-González
Apr 9, 2013·Heart Failure Clinics·Matthew H TranterAlexander R Lyon
May 8, 2013·International Journal of Cardiology·Federico MiglioreGiuseppe Tarantini
Feb 4, 2014·International Journal of Cardiology·John E Madias
Oct 20, 2012·Journal of cardiology·Satoshi Kurisu, Yasuki Kihara
Aug 20, 2016·Future Cardiology·Natale Daniele BrunettiMatteo Di Biase
Sep 18, 2016·Heart Failure Clinics·Elmir Omerovic
Jul 18, 2016·International Journal of Cardiology·Petr A Sarapultsev, Alexey P Sarapultsev
Jan 15, 2020·European Cardiology·Chiara Di FilippoCarlo Di Mario
Mar 24, 2018·Current Neurology and Neuroscience Reports·M RanieriA Bersano
Sep 17, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Shams Y-Hassan, Per Tornvall
Aug 8, 2021·Journal of Clinical Medicine·John E Madias

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.