Haemodynamic Responses to Selective Vagal Nerve Stimulation under Enalapril Medication in Rats

PloS One
Mortimer GierthmuehlenDennis T T Plachta

Abstract

Selective vagal nerve stimulation (sVNS) has been demonstrated to lower blood pressure (BP) in rats without causing major side effects. This method might be adapted for the treatment of therapy-resistant hypertension in patients. Converting enzyme inhibitors (CEIs) are among the first drugs that are administered for arterial hypertension and prominently reduce BP primarily by interacting with the renin-angiotensin system of the kidneys. Beyond the reduction of BP, CEI have a positive effect on the survival rate after myocardial infarction; they reduce the rates of stroke and improve the neurohormonal status in heart-failure patients. If sVNS might be introduced as a therapy against resistant hypertension, patients will at least partially stay on their CEI medication. It is therefore the aim of this study to investigate the influence of the CEI enalapril on the haemodynamic and respiratory effects of sVNS. In 10 male Wistar rats, a polyimide-based multichannel-cuff-electrode was placed around the vagal nerve bundle to selectively stimulate the aortic depressor nerve fibres. Stimulation parameters were adapted to the thresholds of the individual animals and included repetition frequencies between 30 and 50 Hz, amplitudes of 0.5 t...Continue Reading

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Citations

May 26, 2016·Advances in Therapy·Dennis T T PlachtaMortimer Gierthmuehlen
Jul 3, 2016·Current Hypertension Reports·Fu L NgMelvin D Lobo
May 22, 2019·Cold Spring Harbor Perspectives in Medicine·Michael J CapilupiLance B Becker
Feb 8, 2020·Current Hypertension Reports·Mortimer GierthmuehlenJosef Zentner
Jun 11, 2021·Frontiers in Neuroscience·Adam FitchettKirill Aristovich
Jun 28, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Mortimer GierthmuehlenDennis T T Plachta

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