Haemoglobin A1c variability as an independent correlate of atherosclerosis and cardiovascular disease in Chinese type 2 diabetes

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Yifei MoWeiping Jia

Abstract

To examine the association between haemoglobin A1c variability and macrovascular complication in type 2 diabetes. We retrospectively enrolled 5278 diabetes patients with no history of cardiovascular disease and atherosclerosis by ultrasound at their first visit to the hospital from 1999 to 2010. Patients had a median of 4 haemoglobin A1c (range = 3-9) measurements during follow-up. Average haemoglobin A1c and haemoglobin A1c variability were calculated as intra-individual mean, standard deviation, coefficient of variation and adjusted standard deviation. Cardiovascular disease events and ultrasound results were re-evaluated from the medical history at the end of the study. A total of 972 patients had macrovascular complication. Compared to those without atherosclerosis/cardiovascular disease (n = 4306), haemoglobin A1c intra-individual mean and haemoglobin A1c variability levels were significantly higher in patients with macrovascular complication ( p < 0.001). Multivariable logistic regression analysis showed that haemoglobin A1c variability was associated with macrovascular complication. Moreover, 488 patients with only atherosclerosis had significantly higher haemoglobin A1c intra-individual mean and haemoglobin A1c variabil...Continue Reading

References

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Jun 10, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·J C PrenticeP R Conlin

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Citations

Mar 19, 2019·Diabetes/metabolism Research and Reviews·Yuqian BaoUNKNOWN Chinese Diabetes Society
Jul 6, 2020·Cardiovascular Diabetology·Zheng ZhouMeng Bian
May 1, 2021·Journal of Clinical Medicine·You-Ting LinChing-Chu Chen

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BETA
amputation

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SPSS

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