Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer

World Journal of Gastroenterology : WJG
Shuai-Shuai XuXian-Jun Yu

Abstract

Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutrition status. However, no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection. To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients. The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection. The relationship between postoperative survival and the preoperative level of HALP was investigated. Low levels of HALP were significantly associated with lymph node metastasis (P = 0.002), poor tumor differentiation (P = 0.032), high TNM stage (P = 0.008), female patients (P = 0.005) and tumor location in the head of the pancreas (P < 0.001). Low levels of HALP were associated with early recurrence [7.3 mo vs 16.3 mo, P < 0.001 for recurrence-free survival (RFS)] and short survival [11.5 mo vs 23.6 ...Continue Reading

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Citations

Oct 20, 2020·International Journal of Clinical Practice·Coskun KayaCemil Aydın
Feb 16, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lin-Min ChenHui-Ying Qin
Mar 10, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yu-Yu DuanYan He

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